Roles of transient receptor potentials in itch and inflammation in allergic status

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14867
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Tanaka Akane 東京農工大学, (連合)農学研究科(研究院), 教授 (80418673)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 臨床病理 / アトピー性皮膚炎

Outline of Final Research Achievements

Peripheral perception, including sensations of pain and itch, functions as host protection from external stimuli. However, over or abnormal activation of peripheral neuronal systems sometimes induce unpleasant sensation to hosts. Although itch sensation is one of the most unbearable clinical symptoms in patients with atopic dermatitis, the exact mechanism that maintains chronic itch in allergic status has not been fully understood. Recent studies have suggested the role of TRP channels in itch sensation appeared in allergic skin diseases. Therefore, in the present study, we attempted to investigate association of TRP channels in pathogenesis of atopic dermatitis by using TRP channels deficient NC/Tnd mice.

Free Research Field

臨床獣医学