2016 Fiscal Year Final Research Report
Studies on autoimmune responses in molecular pathology of canine demodicosis
| Project/Area Number |
15K14869
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 犬毛包虫症 |
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| Outline of Final Research Achievements |
The skin sample obtained from a dog that had suffered canine demodicosis were successfully transplanted in three NOD-SCID mice. CD8+ lymphocytes collected from three dogs (a dog which skin had been collected, a dog with canine demodicosis, a healthy dog) were then transferred to the mice. The lymphocyte transfer did not induce any clinical signs. Forty two days after the lymphocyte transfer, a dermatopathological examination was performed and indicated no inflammation in epidermis, dermis and follicles. These were no significant difference on pathological findings among three different mice.
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| Free Research Field |
皮膚免疫学
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