Screening of candidate genes associating with the progression of chronic kidney disease in mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14873
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: Hokkaido University
• Principal Investigator: Ichii Osamu 北海道大学, 獣医学研究科, 准教授 (60547769)
• Co-Investigator(Renkei-kenkyūsha): HORINO TARO 高知大学, 医学部, 講師 (90448382)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 慢性腎臓病（CKD） / 嚢胞 / 原因遺伝子 / 遺伝子座 / ゲノム / 病理 / マウス / 遠位尿細管

Outline of Final Research Achievements

Chronic kidney disease (CKD) is a serious problem from the points of increase of the patients with CKD as well as medical economy. In the present study, we discovered the candidate locus associating with the progression of CKD in DBA/2 mouse inbred strain. We named this locus as DBA/2 renal cyst“drecy”. From the pathological analysis, drecy locus related to the alternation of molecules associating with the transportations of ion or vesicle and cell-adhesion in the epithelial cells of distal tubules. We considered that these alternations would lead the abnormal phenotypes of distal tubules, including cyst formation. Furthermore, gene expression analysis suggested that the genes encoded on DBA/2-type chromosome 12 (D12Mit182-83), in particular Greb1, associate with the progression of these phenotypes.

Free Research Field

獣医学、腎臓病学、分子形態学