2017 Fiscal Year Final Research Report
Study for utilization of rice seed protein body for medical protein delivery to intestinal tract
| Project/Area Number |
15K14923
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied molecular and cellular biology
|
|---|
| Research Institution | Kyoto Prefectural University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 医療用タンパク質 / イネ種子 / 胚乳 / プロテインボディ / プロラミン / ドラッグウデリバリー / 形質転換イネ / 植物 |
|---|
| Outline of Final Research Achievements |
Our group has analyzed in detail the mechanism by which endogenous prolamin accumulates in the protein body-I (PB-I) existing in rice seed. This is a challenging study aimed at creating new drug delivery system using transgenic rice. In this research, we added new technology to the mechanism, localize medical protein to a specific region of PB-I, drug delivery to intestinal tract of human or domestic animals, so that a small amount of highly effective micro-container for medicine.
From the results of 3 years of research, the promoter sequence of prolamin is important for localizing the medical protein to a specific region of PB-I, and in order to stably accumulate in PB-I, It was revealed that the prolamin coding sequence was necessary. This result is expected to greatly contribute to research and development of oral vaccine rice in the future.
|
| Free Research Field |
農学
|
