2016 Fiscal Year Final Research Report
Debelopment of nano satelite-organized archetecture as a technology to control an intracellular trafficking
| Project/Area Number |
15K14934
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University (2016)
Hokkaido University (2015) |
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Principal Investigator |
Akita Hidetaka 千葉大学, 大学院薬学研究院, 教授 (80344472)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 細胞内動態 / ナノ粒子 |
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| Outline of Final Research Achievements |
For the development of efficient gene carrier, hierarchically ordered nano-architecture on which functional devices (ligand for specific tissues/cells/organelles) could be placed in desired manner was formulated. Environment sensitive lipid like material which we refer as to SS-cleavable Proton-Activated Lipid-like Material (ssPalm) was employed as a basis of nano-architecture. The hierarchical nano-architecture, Nano-size Satellite-type Organized Lipid-nanoparticle Assembly (Nano-SOLA), was fabricated via double strand formation of PEGylated complementary oligo DNA. The Nano-SOLA composed of multiple primary particles were recognized as one complex by the cells.
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| Free Research Field |
薬剤学
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