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2017 Fiscal Year Final Research Report

New stem cell therapy base on freeze drying

Research Project

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Project/Area Number 15K14944
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionYokohama City University (2016-2017)
Tokyo University of Science (2015)

Principal Investigator

HORIGUCHI Michiko  横浜市立大学, 医学研究科, 客員研究員 (70632470)

Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsDDS / 吸入剤 / 移植 / 再生治療 / COPD / 難治性肺疾患
Outline of Final Research Achievements

Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease, leading to a widespread and irreversible alveolar collapse.The COPD becomes the third position of the world cause of death. The aim of this study was to identify a treatment target molecule able to regenerate collapsed alveoli. This study is the first one to identify lung stem cells and ECM factor that induce lung repair. The stability of nanoparticles of stem cells and ECM factor significantly increased in comparison with the controls, and pulmonary administration of the nanoparticles regenerated collapsed alveoli. These results suggest that lung stem cells and ECM nanoparticles are effective as novel COPD treatment target compounds.

Free Research Field

再生治療

URL: 

Published: 2019-03-29  

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