2016 Fiscal Year Final Research Report
Discovery of anti-cancer effects of existing drugs by data-driven drug repositioning
| Project/Area Number |
15K14980
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | インシリコ創薬 / 既存薬再開発 / 適応拡大 / がん |
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| Outline of Final Research Achievements |
In this study, we developed a method of drug repositioning for cancer (a drug discovery strategy to identify new effects of existing drugs for treatment of other diseases) based on large-scale data on drugs, genes, proteins and diseases. We performed a computational prediction of anticancer effects of drugs against various cancers, and investigate the prediction result by wet-lab experiment. We were able to confirm the validity of the predicted anticancer effects of some drugs through interaction with cancer therapeutic target molecules.
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| Free Research Field |
バイオインフォマティクス
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