2016 Fiscal Year Final Research Report
Discovery of demethylase/deacetylase modulators towards therapy for hereditary diseases
| Project/Area Number |
15K14982
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Suzuki Takayoshi 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90372838)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 遺伝性疾患 / エピジェネティクス / 脱メチル化酵素 / 脱アセチル化酵素 / 阻害剤 / 活性化剤 |
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| Outline of Final Research Achievements |
In this study, aiming to find therapeutic agents for hereditary diseases such as beta-globin disorder and Cornelia de Lange syndrome, we attempted to identify lysine-specific demethylase 1 (LSD1) inhibitors and histone deacetylase 8 (HDAC8) activators. Rational drug design and screening allowed us to identify highly selective and potent LSD1 inhibitors and HDAC8 activators.
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| Free Research Field |
創薬化学
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