Studies on adjuvant chemicals predicted by activation of a nociceptive receptor TRPA1

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14990
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental and hygienic pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: Imai Yasuyuki 静岡県立大学, 薬学部, 教授 (80160034)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Tatsuo 静岡県立大学, 食品栄養科学部, 教授 (10210915)
• Research Collaborator: MANABE Kei ; KONISHI Hideyuki ; Sumalee Panthong , Ph.D. ; Arunporn Itharat , Ph.D.
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 環境衛生学 / アレルギー・ぜんそく / 免疫学 / 薬学 / 神経科学

Outline of Final Research Achievements

We studied chemicals that help sensitization to other allergens (adjuvant effect) in relation to the skin irritation. We examined activation of a nociceptive receptor of sensory neurons, transient receptor potential ankyrin 1 (TRPA1) channels by chemicals. We also examined adjuvant effects of chemicals by means of mouse contact hypersensitivity against fluorescein isothiocyanate (FITC). Both activities were found not only in phthalate esters but also in an alternative plasticizer adipate ester, butyl paraben, dibutyl maleate and tributylin, which is a triglyceride. We also found both activities in piperine, a TRPV1 agonist. We could further extend our knowledge of a relationship between TRP channel stimulation and adjuvant activity on skin sensitization.

Free Research Field

免疫学、微生物学