2017 Fiscal Year Final Research Report
Mechanisms underlying endothelial metallothionein induction based on the strategy of bioorganometallics
| Project/Area Number |
15K14992
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Kaji Toshiyuki 東京理科大学, 薬学部薬学科, 教授 (90204388)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バイオオルガノメタリクス / メタロチオネイン / 有機-無機ハイブリッド分子 / 誘導 / 血管内皮細胞 |
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| Outline of Final Research Achievements |
The present study revealed that induction of metallothionein (MT) isoforms MT-1 and MT-2 of vascular endothelial cells mediated by the MTF-1-MRE pathway and Nrf2-ARE pathway, respectively, using organic-inorganic hybrid molecules. Additionally, it was also revealed that induction of MT-1A and MT-2A is mediated by the ALK5-Smad2/Smad4-Sp1 pathway and ALK5-Smad2-Sp1pathway, respectively. It has been postulated that there is no functional difference between MT-1 and MT-2, however, the present results suggest the functional differentiation between the MT isoforms.
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| Free Research Field |
環境健康学，毒性学，バイオオルガノメタリクス
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