2016 Fiscal Year Final Research Report
The role of exosome on molecular clock in organ dysfunction
| Project/Area Number |
15K15005
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 薬学 / 分子時計 / エキソソーム / 病態 |
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| Outline of Final Research Achievements |
Chronic kidney disease (CKD) increases the disease risk of liver dysfunction, apoplexy, cardiac failure, cardiac infarction and neurological complications. However, the role of exosome on molecular clock in organ dysfunction remain unclear. Here, we showed the disruptive effect of chronic renal failure in 5/6 nephrectomy mice on the 24-hr rhythm of clock gene expressions regulating cytochrome P450 (CYPs) in liver. These disruptive effects of clock genes were reflected by the alteration of molecular clock in exosome.
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| Free Research Field |
時間薬剤学
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