Development of novel multi-target drugs for intractable amyloidoses

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15006
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: Jono Hirofumi 熊本大学, 医学部附属病院, 准教授 (40515483)
• Research Collaborator: Butler James
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 高機能性遺伝子キャリア / アミロイドーシス / 家族性アミロイドポリニューロパチー

Outline of Final Research Achievements

Intractable amyloidoses progress through 3 critical pathological processes, 1. Overproduction or mutation of amyloid precursor proteins, 2. Amyloid fibril formation caused by conformational change, 3. Tissue deposition of amyloid fibrils. However, as of this moment, no clinically effective therapy targeting each pathological process independently is available. In this research, we utilized characteristic features of polyamidoamine starburst dendrimer as a multifunctional material and developed novel multi-target drugs (GUG-β-CDE) for FAP effectively suppressing 3 pathological process in parallel.

Free Research Field

医療系薬学