Functional analysis of "angio-lymphatic vessels" in the neoplastic lesions - its histopathological significance

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15011
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Hirosaki University
• Principal Investigator: Kijima Hiroshi 弘前大学, 医学研究科, 教授 (90204859)
• Co-Investigator(Kenkyū-buntansha): 下田 浩 弘前大学, 医学研究科, 教授 (20274748)
• Co-Investigator(Renkei-kenkyūsha): MOROHASHI SATOKO 弘前大学, 大学院医学研究科, 助教 (90569592) ; WU YUNYAN 弘前大学, 大学院医学研究科, 助教 (40636586)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血管新生 / 腫瘍細胞 / 浸潤性増殖 / 血行性転移 / リンパ行性転移

Outline of Final Research Achievements

Angiogenesis and stromal invasion play important roles in tumor growth/extension. We have identified angio-lymphatic vessels positive for both vascular marker (factor VIII) and lymphatic marker (D2-40). We examined histopathological characteristics of the aigio-lymphatic vessels in the tumors. The angio-lymphatic vessels are found not only tumor tissues, but also their surrounding tissues, and thought to play a significant role in early tumor invasion and neoangiogenesis.

Free Research Field

病理組織学