Mechanisms of interaction between the volume-sensitive outwardly rectifying anion channel, VSOR, and a novel membrane protein, LRRC8A.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15028
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: The Graduate University for Advanced Studies
• Principal Investigator: OKADA Yasunobu 総合研究大学院大学, なし, 学長 (10025661)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: アニオンチャネル / 細胞容積調節 / タンパク質－タンパク質相互作用 / 細胞生理学

Outline of Final Research Achievements

Recently, LRRC8A was reported to be the essential component of human volume-sensitive outwardly rectifying anion channel (VSOR). In this study, we have elucidated that LRRC8A is also essentially involved in mouse VSOR activity, whereas it is not involved in the activities of 4 other types of anion channels activated by acid, Ca2+, patch excision or cAMP, respectively. Also, we have shown that deficiency of VSOR activity in KCP-4 cells is not due to insufficient expression of LRRC8A/B/C/D/E, suggesting an involvement of some other molecule(s) in VSOR activity.

Free Research Field

生理学一般