2016 Fiscal Year Final Research Report
Development of SOI detector adopted for recording single molecular dynamics of proteins
| Project/Area Number |
15K15030
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Yasuo Arai 高エネルギー加速器研究機構, 教授 (90167990)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 1分子計測 / X線回折 / 蛋白質 |
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| Outline of Final Research Achievements |
Single-molecular conformational changes of proteins have been recorded by diffracted X-ray tracking method in which the diffraction spots from a gold nanocrystal, attached to the protein, were tacked on the two dimensional X-ray detector. In some cases the entire motions were not recorded because the size of X-ray receiving surface was insufficient. Aiming to resolve this issue we examined whether the Silicon-On-Insulator (SOI) sensor whose pixel size is very small (~17micron) can be used for or not.
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| Free Research Field |
生物物理学・生理学
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