Molecular mechanism of overeating regulated by cellular stress response

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15038
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kanazawa Medical University (2016); Gunma University (2015)
• Principal Investigator: IWAWAKI Takao 金沢医科大学, 総合医学研究所, 教授 (50342754)
• Research Collaborator: AKAI Ryoko 金沢医科大学, 総合医学研究所, 研究補助員
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 小胞体ストレス / 過食

Outline of Final Research Achievements

Our focus is on molecular mechanism of overeating regulated by endoplasmic reticulum (ER) stress in this research. In the first year we have performed elaborate analysis of overeating itself and preliminary analysis of function of hormones and neurons when overeating is induced. In the second year we have performed screening of responsive genes for overeating and functional analysis of the genes. These analyses revealed that ER stress inducible overeating is not caused by abnormal regulation of leptin and ghrelin, and that specific neurons and genes are responsible for ER stress inducible overeating. We also found interaction between an ER stress responsive molecule and a receptor of regulatory hormone in food intake.

Free Research Field

分子細胞生物学