Molecular basis for regulation of feeding and food-entrained rhythms via brain-bone marrow network

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15040
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Nagoya University (2016-2017); Kinki University (2015)
• Principal Investigator: Hayasaka Naoto 名古屋大学, 環境医学研究所, 特任准教授 (80368290)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨髄 / 摂食リズム / 制限給餌

Outline of Final Research Achievements

In this study, we found a significant change in the expression of clock genes in the bone marrow and hypothalamus under restricted feeding and fasting. In parallel, it was also indicated that changes in the phase of clock gene expression were observed under restricted feeding. In the case of myeloablative destruction, abnormality of restricted feeding rhythm, that is, a significant reduction in feeding action (FAA) was observed under fasting. Furthermore, when we examined KO mice in which a gene with elevated expression under fasting is ablated, we observed a significant decrease in FAA. Collectively, our data suggest that food-entrainable oscillator (FEO) may constitute a network including bone marrow and hypothalamus. It was also suggested that a certain signaling from the bone marrow to the brain is involved in FAA induction under the control of FEO. Overall, our study suggest a novel mechanism in which not only brain but other regions play a role in the regulation of behavior.

Free Research Field

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