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2016 Fiscal Year Final Research Report

Proof-of-concept of nucleic acid medicine for cardiac channelopahy in an animal model

Research Project

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Project/Area Number 15K15049
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Furukawa Tetsushi  東京医科歯科大学, 難治疾患研究所, 教授 (80251552)

Research Collaborator IHARA Kensuke  
SASANO Tetsuro  
Project Period (FY) 2015-04-01 – 2017-03-31
Keywords不整脈
Outline of Final Research Achievements

Cardiac channelopathy is a main cause of familiar sudden death; because of lack of efficient therapy, the establishment of novel therapeutic strategy is warrated. I have established an animal model of cardiac channelophy by introducing gain-of-function mutant, with use of which I tried to establish a novel therapeutic strategy of cardiac channelopathy. Originally, I planned to reduce gain-of-function mutant gene using oligonucleic acid. However, oligonucleic acid was mainly introduced into the liver, causing liver toxicity as a side action. Then, I changed our plan to use Crispr/Cas9 genome editing strategy. I was sucdeeded in introducing Crispr/Cas9 vector into cardiomyocytes, genome editing in cardiac myocytes, and modulating cardiac ion channel function.

Free Research Field

循環器内科

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Published: 2018-03-22  

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