A new mice model of bipolar disease for the drug developments

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15050
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: University of Toyama
• Principal Investigator: Nitta Atsumi 富山大学, 大学院医学薬学研究部(薬学), 教授 (20275093)
• Co-Investigator(Renkei-kenkyūsha): Muramatsu Shin-Ichi 自治医科大学, 医学部, 教授 (10239543)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ピッコロ / 双極性障害 / 光遺伝学 / マウスモデル / ＡＡＶ / 行動実験

Outline of Final Research Achievements

Bipolar disorder has both mania and depression phase and is occurred in adolescent period in human. There were no model animals when our study was started, because the cause of the disease was not clear, then there was no fundamental therapeutic medicines. We succeeded in creating bipolar disorder model mice by knock down of the psychological diseases-related molecule “Piccolo” in the frontal cortex. Furthermore, in order to elucidate the cause of bipolar disorder using this model, we conducted the optogenetics and the in vivo microdialysis method or multi-electrode extracellular potential recording system. We clarified the cause of the pathogenesis of bipolar disorder in part at the least. The mice model should be used for novel therapies for the bipolar disorder.

Free Research Field

神経精神薬理学、薬物治療学、医療薬学