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2017 Fiscal Year Final Research Report

Comprehensive metalomics of cancer cells and tissues

Research Project

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Project/Area Number 15K15063
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionAichi Gakuin University (2016-2017)
Nagoya University (2015)

Principal Investigator

Takei Yoshifumi  愛知学院大学, 薬学部, 教授 (70362233)

Co-Investigator(Renkei-kenkyūsha) HIRATA Takefumi  東京大学, 大学院理学系研究科, 教授 (10251612)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords癌転移 / 微量金属 / 質量分析 / 癌組織 / 脱タンパク質法
Outline of Final Research Achievements

We successfully established to comprehensively measure the amounts of trace metals in cancer cells/tissues via ICP-MS method. Prior to ICP-MS, we performed deproteinization by trichloroacetic acid treatment. Using our method, we showed rubidium (atomic number 37) contents were significantly high in metastatic cell line from human scirrhous gastric cancers compared with the non-metastatic parental cell line. As the next experimental project, we obtained a precious cue to research the relationship between cancer metastasis and rubidium contents.

Free Research Field

生化学

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Published: 2019-03-29  

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