2016 Fiscal Year Final Research Report
Role of ERAP1 in the pathogenesis of mental disorders
| Project/Area Number |
15K15088
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Teikyo Heisei University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 小胞体アミノペプチダーゼ / ノックアウトマウス / セロトニン |
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| Outline of Final Research Achievements |
Role of ERAP1 in the pathogenesis of mental disorder was investigated using ERAP1 knock out mouse. All the pharmacological measurements tested including, tail suspension test, forced swim test, elevated plus maze test and three chamber test, showed a significant difference between ERAP1 knockout mouse and wild-type mouse and thus suggested that knockout mouse were suffering mental disorder. Measurement of neuronal signal molecules indicated an increase of serotonin in the brain via activation of serotonin synthetic pathway.
Considering that ERAP1 can be secreted into outside of the cells by certain stimuli, these results strongly suggest that the enzyme plays a critical role in the pathogenesis of certain mental disorders via affecting gene expression of serotonin biosynthesis. Our data presented in this study might confirm new pathological functions of the enzyme and bring new insights into the pathogenesis of certain mental disorders.
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| Free Research Field |
生化学
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