To reveal regulatory mechanisms and strategy for regulation of susceptibility to immune-related diseases and infectious diseases by IkBL molecule

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15095
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: kimura Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 遺伝子 / ウイルス / 感染症 / 免疫学 / 生体分子

Outline of Final Research Achievements

Aim of this study was to investigate the functional involvement of HLA-linked IkBL gene (NFKBIL1) in the regulation of susceptibility to infectious disease and immune-related diseases, especially focusing on HIV infection. By analyzing polymorphisms in IkBL promoter region, it was found that susceptibility to HIV infection as associated with low expression allele of IkBL. By using T cell line and epithelial cell line overexpressing IkBL, it was suggested that IkBL inhibited replication of HIV. In addition, it was observed that spicing of many genes was regulated by IkBL. Furthermore, a novel HIV infection-related gene, of which splicing was regulated by IkBL, was identified to be involved in the regulation of HIV infection.

Free Research Field

人類遺伝学