Development of early clinical reagents for Alzheimer's disease using citrullinated proteins as index

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K15104
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: Ishigami Akihito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50270658)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 神経変性疾患

Outline of Final Research Achievements

We have identified for the first time citrullinated Alzheimer's disease-related proteins in the brains of Alzheimer's disease patients. We also succeeded in developing clinical laboratory diagnostic reagents that quantify it’s citrullinated proteins. It has potential to be useful as a clinical diagnostic agent for quantifying citrullinated Alzheimer's disease-related proteins. In the future, we will verify the usefulness as an early clinical diagnostic agent for Alzheimer's disease.

Free Research Field

老化

Academic Significance and Societal Importance of the Research Achievements

アルツハイマー病の早期臨床検査試薬は未だ開発されていない。本研究成果は、アルツハイマー病を診断する臨床診断薬に繋がる可能性がある。