Immune suppressive function of allogeneic hematopoietic stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K15109
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: The University of Tokyo
• Principal Investigator: Otsu Makoto 東京大学, 医科学研究所, 准教授 (30361330)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Satoshi 東京大学, 医科学研究所, 准教授 (60226834)
• Research Collaborator: LAI Chen-Yi 東京大学, 医科学研究所, 特任研究員 (30739925) ; ISHIDA Takashi 北里大学, 医学部, 客員研究員
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: 造血幹細胞 / 移植 / 移植片対宿主病

Outline of Final Research Achievements

Hematopoietic cell transplantation is widely recognized as an effective therapeutic measure. However, graft-vs-host disease (GvHD) remains one of major serious adverse events. This study attempted to demonstrate that hematopoietic stem (progenitor) cells (HSPCs) themselves had previously unrevealed ability to suppress GvHD. Although preliminary, established mouse models showed such effects in HSPCs after transplantation.

Free Research Field

造血幹細胞