Control of intestinal diseases by autophagy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15110
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ASANO Junpei 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 (70463809)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: オートファジー / 腸管上皮 / 幹細胞

Outline of Final Research Achievements

The involvement of autophagy in various diseases is being clarified, and autophagy has attracted attention from the viewpoint of disease control. In this study, we focusing on inflammatory bowel disease (IBD) which has been increasing in recent years, the possibility of autophagy disease control was examined. We confirmed that autophagy is important for intestinal stem cell homeostasis and intestinal epithelium regeneration. Furthermore, inflammation exacerbations of intestinal epithelium lacking autophagy were confirmed in mouse enteritis model using 5-FU. This study revealed that autophagy is important for regeneration of the intestinal epithelium, suggesting the usefulness of autophagy in the clarification and control of IBD pathogenesis.
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Free Research Field

免疫学