Development of a new transmission-blocking method against malaria, using rare sugar-containing sugar solution as food for vector mosquitoes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15123
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Kagawa University
• Principal Investigator: ARAI Meiji 香川大学, 医学部, 准教授 (30294432)
• Co-Investigator(Kenkyū-buntansha): 平井 誠 順天堂大学, 医学部, 准教授 (50326849)
• Co-Investigator(Renkei-kenkyūsha): TOKUDA Masaaki 香川大学, 医学部, 教授 (10163974)
• Research Collaborator: TERANAKA Masato 香川大学, 医学部, 教務職員 (20294770)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マラリア / ハマダラカ / 伝播阻止 / 希少糖 / D-アロース / ヘキソース・トランスポーター

Outline of Final Research Achievements

We demonstrated that D-allose, a kind of rare sugars, has strong transmission-blocking effect against rodent malaria parasite, Plasmodium berghei, in the vector mosquito Anopheles stephensi. Furthermore, rare sugar-containing syrup widely available at stores has been shown to possess transmission-blocking effect which is comparable in efficacy to D-allose. These results will have a striking positive impact for developing a new transmission-blocking method using rare sugars in malaria-endemic countries.

Free Research Field

寄生虫学