2017 Fiscal Year Final Research Report
Pattern recognition receptors of C. elegans and the target molecules
| Project/Area Number |
15K15133
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMURA Tomomi 奈良女子大学, 生活環境科学系, 助教 (10736515)
NAKADAI Eriko 大阪市立大学, 大学院生活科学研究科, 准教授 (40453790)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 細菌 / 乳酸菌 / 老化 / 感染症 / 生体防御 / 自然免疫 / 栄養 / 機能性食品因子 |
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| Outline of Final Research Achievements |
Bifidobacteria (BI) enhance the host defense of C. elegans and bring the longevity and tolerance to infection. This study was to reveal what is the pattern recognition receptor (PRR) of the worm and which molecule of BI binds to the receptor for the probiotic effects. A gene was found as a putative PRR; knockdown of the gene made the worms susceptible to infection. Further studies are ongoing to examine if the gene codes the product working as a PRR directly and how the gene is involved in the enhancement of host defense.
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| Free Research Field |
細菌学
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