Establishment of in vitro infection system of hepatitis B virus and infection prevention

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15140
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Kanazawa University
• Principal Investigator: KUROKI Kazuyuki 金沢大学, がん進展制御研究所, 准教授 (20178122)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Ｂ型肝炎ウイルス / HBV / iPS細胞 / 肝細胞 / ウイルス / 感染

Outline of Final Research Achievements

Understanding the Life cycle of human hepatitis B virus (HBV), the causal virus of hepatitis and liver cancer, is important in exploring new ways to prevent the infection and proliferation of HBV. In this study, as a foothold to elucidate the molecular mechanism of hepatocyte-specific infection of HBV which is not well understood yet, and as a basis for anti-HBV drug discovery, we established HBV in vitro infection system with more efficient and reproducible effect on differentiated hepatocytes from newly prepared iPS cells.

Free Research Field

分子ウイルス学