2016 Fiscal Year Final Research Report
Why does sleep disorder cause diseases?
| Project/Area Number |
15K15147
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 炎症 / ストレス / 神経 / ゲートウェイ反射 / 炎症回路 |
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| Outline of Final Research Achievements |
The central nervous system (CNS) equips the blood-brain barrier (BBB) to limit exchanges of substances. However, immune-cell infiltration occurs in CNS. We have identified the dorsal vessels of the fifth lumbar (L5) spinal cord as a gateway for immune cells to CNS, which is critical for neuro-inflammation development. In this proposal, how stress-mediated neural activations affect the gateway was examined. I found that specific nerve activations by sleep disorder completely change the gateway site from L5 to the brain, followed by sudden death by gastrointestinal bleeding. This “stress-gateway reflex” explains a classical proverb “Illness starts in the mind.”, which we generally experience but the mechanisms are not well known. By continuing the gateway reflex research, it can be expected that manipulations of local neural activations will be a new therapeutic approach for certain diseases.
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| Free Research Field |
炎症学
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