2015 Fiscal Year Final Research Report
The role of a transcription factor TFEB in the innate immune system
| Project/Area Number |
15K15148
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Keywords | 自然免疫 |
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| Outline of Final Research Achievements |
The present study focused on the role of a transcription factor TFEB, a master regulator of lysosomes, in Toll-like receptor (TLR) responses. In preliminary studies, TFEB overexpression upregulated TLR responses. However, overexpression by another expression vector did not activate TLR responses. Further study was therefore difficult to pursue. Instead, we focused on the role of mTOR, a regulator of TFEB, in TLR responses, and found that mTORC2 play a role in TLR3 responses.
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| Free Research Field |
免疫学
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