2017 Fiscal Year Final Research Report
Analysis of human senescence-related T cells using cohort study
| Project/Area Number |
15K15151
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
Hamazaki Yoko 京都大学, iPS細胞研究所, 教授 (10362477)
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| Co-Investigator(Kenkyū-buntansha) |
松田 文彦 京都大学, 医学研究科, 教授 (50212220)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | T細胞 / 細胞老化 / 免疫老化 / コホート研究 |
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| Outline of Final Research Achievements |
We obtained flow-cytometry data on immune cells from more than 200 healthy individuals in a cohort of people in Nagahama city, and are analyzing a possible correlation between immune cell phenotypes and laboratory values. In addition, we succeeded in identifying new age-related T cell subset (CXCR3+ naive phenotype CD8 T cells) using thymectomy mouse model and confirmed the existence of CD8 T cells with similar phenotypic and functional properties in human.
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| Free Research Field |
免疫学
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