Development of diagnostic method for lifestyle-related disease risk targeting peripheral blood mononuclear cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15192
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Osaka University
• Principal Investigator: Kihara Shinji 大阪大学, 医学系研究科, 教授 (20332736)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 分析科学 / 蛋白質 / 医療・福祉 / 細胞・組織 / マイクロアレイ

Outline of Final Research Achievements

Based on the mRNA microarray analysis of peripheral blood mononuclear cells before and after meal load, we identified suppressor of cytokine signaling (SOCS) 1 and SOCS 3 and inflammation control secretory protein factor A (unpublished data) as a molecule group responsive to oxidative stress occurring after meal.
Measurement of these factors might be expected to become a new index to evaluate chronic inflammation leading to lifestyle-related diseases.

Free Research Field

臨床検査医学