Control of amyloid neuropathy from the aspect of inflammation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15195
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Kumamoto University
• Principal Investigator: ANDO Yukio 熊本大学, 大学院生命科学研究部(医), 教授 (20253742)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 家族性アミロイドポリニューロパチー / トランスサイレチン / 炎症 / サイトカイン / マクロファージ / アミロイド沈着機構 / インターロイキン / 免疫細胞

Outline of Final Research Achievements

To elucidate the role of inflammation on the pathogensis of familial amyloid polyneuropathy (FAP), we measured the concentrations of various kinds of cytokines, and counted the T, B and monocytes in the peripheral blood in FAP patients and controls. Those analyses revealed activated inflammatosome, such as inflammatory related cytokines, and monocytes secreted IL-1β and IL-6. NO significant results were obtained in the compliment association in those analyses. Immunohistochemical analyses revealed that, M2 macrophages might play an important role in the amyloidogenesis of this disease in compared to immunohistochemical findings in controls, those in FAP patients.

Free Research Field

神経内科、アミロイド―シス学、検査医学