2016 Fiscal Year Final Research Report
Construction of the system of
| Project/Area Number |
15K15196
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | microRNA / 血管内皮細胞 / 単核球 |
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| Outline of Final Research Achievements |
The evaluation of vascular endothelial function is mainly based on physiological function tests, such as ABI and FMD, which measure vasodilatation action. Since nitric oxide (NO) regulates the elasticity of blood vessels, we examined miRNAs that cause alteration of the level of NO. Vascular endothelial cells, HUVEC and HAEC, increase NO production by insulin and cytokines. Bacterial infection upregulates miR-218 level in monocytic cells. This increase of miR-218 suppresses the level of inflammatory cytokines in monocytic cells, suggesting that monocytic miRNA can indirectly regulate NO production in endothelial cells. We have shown the communication between monocytic cells to endothelial cells control vascular function mediated by mRNAs.
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| Free Research Field |
分子血管学
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