Identification of the pathologically-transited immature cells diagnosed by soluble LR11

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15198
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Toho University
• Principal Investigator: BUJO Hideaki 東邦大学, 医学部, 教授 (80291300)
• Co-Investigator(Renkei-kenkyūsha): JIANG Meizi 東邦大学, 医学部, 非常勤研究生 (00624066) ; SHIMIZU Naomi 東邦大学, 医学部, 講師 (30375802) ; HIRUTA Nobuyuki 東邦大学, 医学部, 准教授 (50201736) ; NAGAO Tateki 東邦大学, 医学部, 教授 (20167555)
• Research Collaborator: NAKASEKO Chiaki 千葉大学, 医学部, 准教授 (30323398) ; IKEUCHI Takeshi 新潟大学, 医学部, 教授 (20372469)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 可溶性 / ＬＲ１１ / 病的細胞 / 検査マーカー / リンパ腫 / 肺高血圧症 / アルツハイマー病

Outline of Final Research Achievements

This study was aimed to identify pathological transition of the immature cells diagnosed by soluble LR11 (sLR11). The role and significance of sLR11 was investigated in three types of diseases with increased circulating sLR11 levels. The malignant transition of hematological cells was detected in the diagnosis of patients with diffuse large B-cell lymphoma. sLR11 was also important as a marker of pathological smooth muscle cells in pulmonary hypertension. The significance of sLR11 for the early diagnosis of Alzheimer’s disease will be further investigated by analysis using the patients’ samples. Thus, sLR11 was identified as a key regulator and a biomarker for the transition to pathological cells in heterogeneous diseases.

Free Research Field

検査医学