Effect of vitamin D insufficiency on major causes of disability: 10-year follow-up of a population-based cohort

2017 Fiscal Year Annual Research Report

• Project/Area Number: 15K15219
• Research Institution: The University of Tokyo
• Principal Investigator: 吉村 典子 東京大学, 医学部附属病院, 特任教授 (60240355)
• Co-Investigator(Kenkyū-buntansha): 村木 重之 東京大学, 医学部附属病院, 登録研究員 (40401070) ; 岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 医療・福祉 / 血清25-hydroxyvitamin D値 / 要介護 / コホート研究 / メタボリックシンドローム / サルコペニア / 骨粗鬆症 / ロコモティブシンドローム

Outline of Annual Research Achievements

本研究は、高齢者の運動器障害や生活の質(QOL)の維持および要介護予防を目的として2005年から追跡を続けている大規模住民コホートにおいて、対象者に10 年目の追跡調査を行い、25-hydroxyvitamin D(25D)値の測定結果および蓄積されたデータを解析して、25D値の要介護移行率への影響を解明する。加えて、要介護の原因としての脳血管障害、認知症、高齢による衰弱（フレイル）、骨粗鬆症(OP)による骨折、関節症のそれぞれリスクをあげる原因疾患であるメタボリック症候群(メタボ)、軽度認知障害(MCI)、筋量減少症(サルコペニア、SP)、OP、OAへの有病率、発生率への影響を明らかにし、要介護予防対策におけるビタミンD（VD）の充足の重要性の有無についてエビデンスを得ることを目的としている。
本年度は山村コホートにおいて10年目（4回目）の調査を実施し、調査時に同意の得られた参加者から、OP、OA、筋肉減少症(サルコペニア、SP)、骨折の判定に必要な骨密度検査、X線検査、筋量検査、握力測定を行った。加えて、25D測定のための血清サンプルも採取し、ディープフリーザーに保存した。これにより、山村、漁村における10年の追跡調査が完了した。
本年度は、コホート調査10年目の血清サンプルにおいて血清25Dの測定を実施した。また山村、漁村住民の追跡調査結果を用いて、SP、フレイルの累積発生率を推定し、血清25D低値がSP、フレイルの発生リスクは上昇させる傾向にあるが有意ではないことを明らかにした。

Research Products

• [Journal Article] Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study. (2018)
  • Author(s): Kodama R, Muraki S, Iidaka T, Oka H, Teraguchi M, Kagotani S, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N
  • Journal Title: Bone Miner Metabol Volume: 36 Pages: 246-253
  • DOI: 10.1007/s00774-017-0834-7
  • Peer Reviewed
• [Journal Article] Radiographic Knee Osteoarthritis and Knee Pain: Cross-sectional study from Five Different Racial/Ethnic Populations. (2018)
  • Author(s): Wang K, Kim HA, Felson DT, Xu L, Kim DH, Nevitt MC, Yoshimura N, Kawaguchi H, Lin J, Kang X, Zhang Y
  • Journal Title: Sci Rep Volume: 8 Pages: 1364
  • DOI: 10.1038/s41598-018-19470-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. (2018)
  • Author(s): Yamada K, Satoh S, Hashizume H, Yoshimura N, Ryohei Kagotani R, Yuyu Ishimoto Y, Abe Y, Toyoda H, Terai H, Masuda T, Muraki S, Nakamura H, Yoshida M
  • Journal Title: J Bone Miner Metab Volume: in press Pages: in press
  • DOI: 10.1007/s00774-017-0901-0
  • Peer Reviewed
• [Journal Article] Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study. (2018)
  • Author(s): Leyland KM, Gates LS, Nevitt M, Felson D, Bierma-Zeinstra SM, Conaghan PG, Engebretsen L, Hochberg M, Hunter D, Jones G, Jordan JM, Judge A, Lohmander S, Roos EM, Sanchez-Santos MT , Yoshimura N, van Meurs JBJ, Batt ME, Newton J, Cooper C, Arden NK
  • Journal Title: Osteoarthritis Cartilage Volume: in press Pages: in press
  • DOI: 10.1016/j.joca.2018.01.024
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Is osteoporosis a predictor for future sarcopenia, or vice-versa? Four-year observations between the second and third ROAD study surveys. (2017)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 28 Pages: 189-199
  • DOI: 10.1007/s00198-016-3823-0
  • Peer Reviewed
• [Journal Article] Association of Lumbar Spondylolisthesis With Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study. (2017)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine (Phila Pa 1976) Volume: 42 Pages: E666-E671
  • DOI: 10.1097/BRS.0000000000001960
  • Peer Reviewed
• [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study. (2017)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 25 Pages: 1122-1131
  • DOI: 10.1016/j.joca.2017.01.001
  • Peer Reviewed
• [Journal Article] Quadriceps muscle strength reference value as index for functional deterioration of locomotive organs: Data from 3617 men and women in Japan. (2017)
  • Author(s): Narumi K, Funaki Y, Yoshimura N, Muraki S, Omori G, Nawata A, Seki R
  • Journal Title: J Orthop Sci Volume: 22 Pages: 765-770
  • DOI: 10.1016/j.jos.2017.03.012
  • Peer Reviewed
• [Journal Article] Sagittal spino-pelvic alignment in adults: The Wakayama Spine Study. (2017)
  • Author(s): Asai Y, Tsutsui S, Oka H, Yoshimura N, Hashizume H, Yamada H, Akune T, Muraki S, Matsudaira K, Kawaguchi H, Nakamura K, Tanaka S, Yoshida M
  • Journal Title: PLoS One Volume: 12 Pages: e0178697
  • DOI: 10.1371/journal.pone.0178697
  • Peer Reviewed
• [Journal Article] MRI-defined paraspinal muscle morphology in Japanese population: The Wakayama Spine Study. (2017)
  • Author(s): Sasaki T, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Iwahashi H, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M
  • Journal Title: PLoS One Volume: 12 Pages: e0187765
  • DOI: 10.1371/journal.pone.0187765
  • Peer Reviewed / Open Access
• [Journal Article] Epidemiological Differences Between Localized and Nonlocalized Low Back Pain. (2017)
  • Author(s): Coggon D, Ntani G, Walker-Bone K, Yoshimura N, et al
  • Journal Title: Spine (Phila Pa 1976) Volume: 42 Pages: 740-747
  • DOI: 10.1097/BRS.0000000000001956
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study (2017)
  • Author(s): Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M
  • Journal Title: Eur Spine J Volume: 26 Pages: 2529-2535
  • DOI: 10.1007/s00586-017-5072-0
  • Peer Reviewed
• [Journal Article] Radiographic measurements of the hip joint and their associations with hip pain in Japanese men and women: the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. (2017)
  • Author(s): Iidaka T, Muraki S, Oka H, Kodama R, Tanaka S, Kawacughi H, Nakamura K, Akune T, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 25 Pages: 2072-2079
  • DOI: 10.1016/j.joca.2017.08.008
  • Peer Reviewed
• [Journal Article] Artificial neural networks to predict future bone mineral density and bone loss rate in Japanese postmenopausal women. (2017)
  • Author(s): Shioji M, Yamamoto T, Ibata T, Tsuda T, Adachi K, Yoshimura N
  • Journal Title: BMC Res Notes Volume: 10 Pages: 590
  • DOI: 10.1186/s13104-017-2910-4
  • Peer Reviewed
• [Presentation] Mutual associations among frailty, sarcopenia and osteoporosis: Four-year observations between the second and third ROAD study surveys. (2018)
  • Author(s): Yoshimura N, Muraki M, Oka H, Iidaka T, Kodama R, Horii C, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: International Conference on Farality & Sarcopenia Research (ICFSR 2018), Miami Beach, USA
  • Int'l Joint Research
• [Presentation] Mutual associations among frailty, sarcopenia, and osteoporosis. (2017)
  • Author(s): Yoshimura N, Tanaka S, Nakamura K
  • Organizer: World Congress of Epidemiology (WCE) 2017, Saitama
  • Int'l Joint Research / Invited
• [Presentation] Does sarcopenia and osteoporosis increase the risk of occurrence of fraility? Four-year observations between the second and third ROAD study surveys. (2017)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2017, Denver, Colorado, USA
  • Int'l Joint Research
• [Presentation] Epidemiology of the locomotive syndrome: 2017 update (2017)
  • Author(s): Yoshimura N, Nakamura K, Tanaka S
  • Organizer: JCR 2017 Scientific meeting, Fukuoka
  • Int'l Joint Research / Invited
• [Presentation] Epidemiology of the locomotive syndrome: The research on osteoarthritis/osteoporosis against disability (ROAD) study. (2017)
  • Author(s): Yoshimura N, Tanaka S
  • Organizer: 19th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2017), Dubai, UAE
  • Int'l Joint Research / Invited
• [Presentation] 一般住民におけるRA関連血清マーカーの陽性率および骨粗鬆症、変形性関節症との関連―The ROAD study― (2017)
  • Author(s): 児玉理恵、村木重之、飯高世子、田中栄、岡敬之、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第90回日本整形外科学会学術総会 仙台市
• [Presentation] ロコモティブシンドローム予防の立場から (2017)
  • Author(s): 吉村典子
  • Organizer: 第30回日本老年学会総会 名古屋市
  • Invited
• [Presentation] 寛骨臼形成不全の疫学：有病率と股関節痛との関連 (2017)
  • Author(s): 飯高世子、村木重之、岡敬之、児玉理恵、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第35回日本骨代謝学会学術集会 福岡
• [Presentation] 運動器疾患の性差：地域住民コホートROADより (2017)
  • Author(s): 吉村典子、村木重之、飯高世子、田中栄
  • Organizer: 第17回日本Men’s Health医学会 東京
• [Presentation] 変形性股関節症と職業活動との関連 (2017)
  • Author(s): 飯高世子、村木重之、岡敬之、堀井千彬、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第19回日本骨粗鬆症学会 大阪市
• [Presentation] 25水酸化ビタミンD (2017)
  • Author(s): 吉村典子
  • Organizer: 第19回日本骨粗鬆症学会 大阪市
  • Invited
• [Presentation] ロコモ度テストを用いたロコモティブシンドロームの有病率: The ROAD study (2017)
  • Author(s): 吉村典子、堀井千彬、飯高世子
  • Organizer: 第76回日本公衆衛生学会総会 鹿児島市
• [Presentation] 変形性股関節症の疫学：有病率と痛みとの関連 -The ROAD study- (2017)
  • Author(s): 飯高世子、堀井千彬、吉村典子
  • Organizer: 第76回日本公衆衛生学会総会 鹿児島市
• [Book] 最新医学別冊診断と治療のABC 変形性関節症 変形性関節症の疫学 (2017)
  • Author(s): 田中栄、吉村典子他
  • Total Pages: 240
  • Publisher: 最新医学社