2016 Fiscal Year Final Research Report
Effects of cupper deficiency on cadmium toxicity
| Project/Area Number |
15K15243
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | カドミウム / 銅 / ラット |
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| Outline of Final Research Achievements |
To consider the effect of cupper in the body on the development of chronic cadmium toxicity, rats were injected with cadmium at 2mg/kg once a week for 3 months (saline to control rats) fed by cupper deficient diets. Cadmium induced an elevation of hepatic cupper concentration, renal tubular dysfunction, renal anemia accompanied with a decrease of serum iron, etc. Feeding cupper deficient diets in addition to cadmium injection, an increase in renal excretion of protein and slight enhancement of anemia were observed. These results suggest that cupper deficiency, although only slightly, have an effect to enhance cadmium toxicity.
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| Free Research Field |
重金属の毒性学
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