Study on a differential diagnostic marker for endogenous and exogenous brain injury: Analysis of COX expression property

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15260
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Legal medicine
• Research Institution: University of Yamanashi
• Principal Investigator: SHOJO Hideki 山梨大学, 大学院総合研究部, 准教授 (60284626)
• Co-Investigator(Kenkyū-buntansha): 馬淵 正 山梨大学, 総合研究部, 助教 (80150308)
• Co-Investigator(Renkei-kenkyūsha): ADACHI Noboru 山梨大学, 大学院総合研究部, 教授 (60282125)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 頭部外傷 / シクロオキシゲナーゼ / 内因性・外因性脳損傷診断マーカー

Outline of Final Research Achievements

The goal of current study was to determine whether cyclooxygenase (COX) is useful as a molecular marker for endogenous and extrinsic brain injury differential diagnosis. Here, we elucidated the molecular dynamics of COX1 and 2, which are involved in inflammation and anti-inflammation of the central nervous system in the damaged brain after trauma. In the brain after trauma, COX1 was predominantly in degenerative neurons, while COX2 was expressed in neurons and macrophages. In addition, COX expression patterns reflect the pathological characteristics of various brain diseases, suggesting that COX may be useful as a molecular marker for endogenous and exogenous brain injury differential diagnosis.

Free Research Field

法医学