2016 Fiscal Year Final Research Report
Cross talk analysis of biological clock and autophagy in wound tissue
| Project/Area Number |
15K15264
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | autophagy / 体内時計 / 創傷治癒 / 損傷の生活反応 / 法医診断 |
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| Outline of Final Research Achievements |
We found that autophagy was quickly suppressed in the skin wound tissue after infliction, which might be a useful marker for wound vitality in the forensic practice. Conversely, we found that Rev-erb-alpha and ROR-gamma of clock genes markedly increased at the protein level in the wound tissue. Since suppression of autophagy by treatment with 3-Methyladenine increased ROR-gamma, autophagy suppression seemed to induce an increase of ROR-gamma protein in the wound tissue.
These changes in the wound tissue revealed that they act on Keap 1/Nrf 2 system and induce the expression of antioxidant genes, thereby contributing to promotion of wound healing.
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| Free Research Field |
法医学
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