2017 Fiscal Year Final Research Report
Identification of Substances that Relate to Irritable Bowel Syndrome
Project/Area Number |
15K15267
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
|
Research Institution | Tohoku University |
Principal Investigator |
Fukudo Shin 東北大学, 医学系研究科, 教授 (80199249)
|
Research Collaborator |
KANAZAWA Motoyori
ENDO Yuka
SHOJI Tomotaka
KANO Michiko
MURATSUBAKI Tomohiko
TANAKA Yukari
SASAKI Ayaka
KOMURO Hazuki
SUGAI Chinami
YAMADA Akiko
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 脳腸相関 / 過敏性腸症候群 / 遺伝子 / ストレス / 炎症 / 消化管運動 / 消化管知覚 / 神経伝達物質 |
Outline of Final Research Achievements |
How to cope with stress-related disorders is a crucial problem to solve in the modern society. Irritable bowel syndrome (IBS) is an appropriate disorder to find a hint to do so. We verified the hypothesis that genetic polymorphism of substances regulating hypothalamic-pituitary-adrenocortical axis may affect the phenotype of IBS via proteins/metabolites. Subjects were IBS patients and healthy controls. DNA was extracted from the blood. Genotyping, phenotyping and psycho-behavioral analyses were performed. These genotypes did not directly relate to IBS phenotypes. However, these genotypes were found to be associated with psycho-behavioral factors relating IBS. The hypothesis was thus supported. Findings in this study have scientific and social significance because they can be expanded to the other stress-related disorders.
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Free Research Field |
心身医学
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