2016 Fiscal Year Final Research Report
Establishment of a diagnostic method of amyloidosis with PET
| Project/Area Number |
15K15268
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Tohoku Medical and Pharmaceutical University (2016)
Tohoku University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | アミロイドーシス / PET |
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| Outline of Final Research Achievements |
In any of the amyloidgenic disorders, it is surmised that the monomer of the amyloid protein itself is not very toxic, while misfolded oligomers could cause damage to organs. It is, therefore, truly important to detect the accumulation of real amyloid fibrils for early and accurate diagnosis of amyloidosis. In order to visualize amyloid deposition, the patients with amyloidosis (Alzheimer's disease, rheumatoid arthritis, multiple myeloma, etc) underwent a positron emission tomography (PET) study with a amyloid specific PET tracer, [11C]-BF227. The PET images revealed significantly robust retention of [11C]-BF227 in the patients with amyloidosis compared to that of the normal control. To our knowledge, this is the first report showing the usefulness of a beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis. Therefore, we will be continuing the effort to improve this PET technology with BF227 for the diagnosis of amyloidosis.
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| Free Research Field |
総合診療
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