2017 Fiscal Year Final Research Report
Elucidation of regulation of intestinal macrophage differentiation from intracellular energy metabolism
| Project/Area Number |
15K15296
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kyorin University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | マクロファージ / 細胞内エネルギー代謝 / サイトカイン産生 |
|---|
| Outline of Final Research Achievements |
Macrophages are classified into M1 type that produces inflammatory cytokines, and M2 typeproducing IL-10 that acts on homeostasis and tissue repair. Regarding intracellular energy metabolism, aerobic glycolysis was mainly used in M1 type, and oxidative phosphorylation was mainly used in M2 type.
We clarified that the glycolysis system in the differentiation process is important for obtaining IL-10 productivity of M2-type macrophages. In addition, it was revealed that in the differentiated M2 type macrophages, in addition to the oxidative phosphorylation pathway conventionally mentioned, the glycolytic - ERK pathway was also used for cytokine production under LPS stimulation.
|
| Free Research Field |
炎症性腸疾患 腸管免疫
|
