The effect of next generation pulse laser system on calcification was evaluated. The first step to develop a new device to treat heavily calcified coronary artery lesions.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15305
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HATANO Yu 東京医科歯科大学, 医学部附属病院, 助教 (00736407)
• Co-Investigator(Kenkyū-buntansha): 磯部 光章 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (80176263) ; 足利 貴志 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教授 (00251512) ; 前嶋 康浩 東京医科歯科大学, 医学部附属病院, 助教 (40401393)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血管石灰化 / レーザー治療

Outline of Final Research Achievements

In this study, we focused on the characteristics of a 405 nm pulse laser and the effect on calcification was investigated. At first, we check the effect of laser irradiation on calcified cell line, we obtained the result that calcification was affected by laser irradiation and elemental analysis showed a decrease in Ca content. We also showed that cell survival was affected by laser irradiation. However, the effect of the laser irradiation was unstable, and we thought that it was necessary to improve the experimental system including laser output. We also planned experiments using the rat aorta, but we found that we could not induce mineralization on the intima of the blood vessel with low protein / high adenine diet.

Free Research Field

循環器内科