Role of C1q/TNF-related protein 1 in ischemic heart disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K15308
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: OUCHI NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
• Co-Investigator(Kenkyū-buntansha): OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515) ; SHIBATA Rei 名古屋大学, 医学系研究科, 寄附講座准教授 (70343689) ; MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: 分子心臓病態学 / 虚血性心疾患

Outline of Final Research Achievements

We found that the adipokine C1q/TNF-related protein (CTRP) 1 is protective against acute cardiac injury following ischemia-reperfusion (I/R). CTRP1 knockout mice showed increased infarct size after I/R compared with control mice, which were accompanied by enhanced apoptosis and inflammatory response in ischemic heart. Administration of CTRP1 to wild-type mice led to reduction of myocardial infarct size following I/R. Furthermore, CTRP1 attenuated apoptosis and inflammatory reaction in cardiac myocytes by its ability to promote cyclic AMP-dependent pathway.

Free Research Field

医歯薬学