The effects of calciprotein particles on cardiorenal syndrome

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15314
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Jichi Medical University
• Principal Investigator: KANEDA Ruri 自治医科大学, 医学部, 准教授 (70465029)
• Research Collaborator: KURO-O Makoto 自治医科大学, 医学部, 教授 (10716864)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 心腎連関 / 微小リン酸カルシウム結晶 / CPP

Outline of Final Research Achievements

The bidirectional disorders between the heart and kidney are focused as “cardiorenal syndrome”. In this project, we investigated the effects of calciprotein particles (CPPs) on cultured cardiomyocytes. We incubated neonatal rat cardiomyocytes with or without synthesized CPPs and performed DNA microarray analysis. In the pathway analysis, CPPs reduced the expression of genes involved in the electron transport chain pathway or the striated muscle contraction pathway. Monocyte chemoattractant protein 1 (Mcp1) gene was up-regulated by CPP stimulation. The transcriptional start site of Mcp1 gene in cardiomyocytes with CPP stimulation was highly enriched with histone H3K4 trimethylation compared with that in cardiomyocytes without CPP.
These data suggest that CPPs might be one of the causative agents for cardiac damage in chronic kidney disease patients and could be a target of therapeutic intervention in cardiorenal syndrome.

Free Research Field

医学　循環器内科学