Approaches to mimic lung tissue stem cell nichies

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15323
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: Betsuyaku Tomoko 慶應義塾大学, 医学部(信濃町), 教授 (60333605)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 再生医療 / 肺上皮幹細胞 / 線維芽細胞 / ニッチ

Outline of Final Research Achievements

In this study, we have established several methods to optimize the culture system of lung stem cells isolated central and peripheral lung epithelium. Especially, our novel finding is to find the method to culture stem cells with fibroblasts as a niche. Our new methods published will be widely used for further investigation of lung stem cells and contribute to lung regenerative medicine.

Free Research Field

呼吸器内科学