Large molecular complex of cell surface in malignant pleural mesotheliom as a novel treatment target

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15324
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Juntendo University
• Principal Investigator: OHNUMA Kei 順天堂大学, 医学(系)研究科(研究院), 准教授 (10396872)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 悪性中皮腫 / CD26 / ソマトスタチン受容体 / ペリオスチン / CD26抗体療法

Outline of Final Research Achievements

Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasm deriving from the pleural mesothelial lining. Despite the modest clinical benefit of a multimodality treatment approach including surgery, combination chemotherapy and radiation, prognosis remains grim with poor overall survival. New approaches based on deregulated pathways and targeted therapies are required to improve survival of MPM patients. We have had a long-standing interest in the role of CD26 in cancer biology and its suitability as a novel therapeutic target in selected neoplasms. Our previous work demonstrated that CD26 is preferentially expressed in MPM cells but not in normal mesothelial cells. Recently, we reported robust in vivo data on the anti-tumor activity of anti-CD26 monoclonal antibody in mouse xenograft models. We herein showed significant novel findings and the early clinical development of a CD26-targeted therapy for MPM, advances that can lead to a more hopeful future for MPM patients.

Free Research Field

小児科学