Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15341
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: Kira Jun-ichi 九州大学, 医学研究院, 教授 (40183305)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 多発性硬化症 / コネキシン / ミクログリア / アストログリア / オリゴデンドログリア

Outline of Final Research Achievements

We previously published paper about the relationship between early loss of connexin and the mechanisms of multiple sclerosis. Thus we wanted to analyze how connexin loss affect to the pathology of MS. The animal model of inducible conditional connexins(Cx43 and 47) knockout mice were successfully developed and used for the analysis. We induced EAE on these mice and found significant differences between these cKO mice and WT controls. These data clearly indicated the importance of connexins as new therapeutic targets.

Free Research Field

神経科学