2016 Fiscal Year Final Research Report
The challenge for the study of unmyelinated fibers in central nervous system
| Project/Area Number |
15K15342
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 無髄神経 / Nav1.2 / 有髄神経 |
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| Outline of Final Research Achievements |
Unmyelinated fibers in central nervous systems(CNS) are not well known. Recently, we found Nav 1.2 localizes on the axons of unmyelinated fibers diffusely, not as concentrated localization in the Ranvier nodes on myelinated fibers. Based on this property, we investigated the localization of unmyelinated fibers in the CNS of mice. We found Nav 1.2 diffuse localization on the axons of mossy fibers in hippocampus, parallel fibers in cerebellum, and projection fibers of striatum which are already know to be unmyelinated. In addition to those fibers, we found diffuse localization of Nav 1.2 on the axons in stria terminals and some part of corpus callosum, We also found unmyelinated fibers by electron microscopy. The results suggest, there are still unknown or uninvestigated unmyeilated fibers in CNS.
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| Free Research Field |
病態脳科学
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