The Interplay between genome and epigenome in the browning of white fat cells and obesity

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15346
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: Waki Hironori 東京大学, 医学部附属病院, 特任准教授 (00466765)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ゲノム / エピゲノム / オープンクロマチン / エンハンサー / SNP

Outline of Final Research Achievements

Generation of brown-like fat cells that express UCP1--the critical protein that mediates energy dissipation in the form of heat--is observed in white adipose tissue of mice under a cold challenge or stimulation by an adrenergic agent. Browning potential of white adipose tissue and susceptibility for obesity are both known to be regulated by genetic factors. In this study, we conducted integrated genetic, epigenetic and gene transcriptional analyses on the browning of inbred mouse strains with different potential for browning.

Free Research Field

糖尿病・代謝内科学